Frequency of Hepatitis B and C Viruses in Patients with Malignancies in a Tertiary Care Hospital, Karachi, Pakistan


  • Zulfiqar Ali Shaikh Dow University of Health Sciences, Karachi
  • Sahar Soomro Dow University of Health Sciences (DUHS), Karachi
  • Fareed Uddin Dow University of Health Sciences (DUHS), Karachi
  • Usama Ahmad KMDC, Karachi
  • Shahkamal Hashmi Ziauddin University, Karachi
  • Syeda Kashaf Zaidi Dr Ruth Pfau Civil Hospital, Karachi
  • Maheen Zaidi JPMC, Karachi
  • Huzefa Ahmed CMH, Hyderabad
  • Noshaba Noor NICH, Karachi
  • Uzma Memon JPMC, Karachi



Hepatitis B, Hepatitis C, oncology, blood transfusion, patients, HCV, HBV


Background: Hepatitis, a viral infection affecting the liver, can progress to cirrhosis or cancer. Hepatitis B and Hepatitis C, distinct viral strains, induce acute or chronic liver inflammation. Individuals with chronic hepatitis face an elevated risk of extra-hepatic cancers. Various hypotheses explore the mechanisms of Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) in tumorigenesis. This study aims to ascertain the prevalence of hepatitis B and C viruses among patients with malignancies in a tertiary care hospital in Karachi.

Methods: We conducted as a cross-sectional study, data were collected from Dr. Ruth Pfau Civil Hospital, Karachi, a tertiary care facility, between May 2020 and July 2020. Out of 257 cancer-diagnosed patients, informed about and assured of the questionnaire's confidentiality, data were collected and analyzed.

Results: Among the 257 patients, 56.42% were females and 43.57% males, with a mean age of 47.5 years. Breast cancer was the most common type, identified in 20.2% of patients. Overall, 36.96% of patients had either HBV or HCV, with no instances of coinfection. Positivity rates were 21.4% for HBV and 15.56% for HCV. No significant associations were observed between cancer types and Hepatitis B Surface Antigen (HBsAg) or Anti-Hepatitis C Antibodies (Anti-HCV Ab).

Conclusion: Close surveillance of cancer patients is crucial, monitoring HBV antibody titers, and enrollment in hepatitis B immunization programs are recommended. Additionally, monitoring Anti-HCV status is advised.




How to Cite

Frequency of Hepatitis B and C Viruses in Patients with Malignancies in a Tertiary Care Hospital, Karachi, Pakistan. (2023). Pakistan Journal of Public Health, 13(3), 138-141.